Salicylic acid
Salicylic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target acid-sensing ion channel 3.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| skin and connective tissue diseases | D017437 |
Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2% salicylic acid facial cleanser | OTC monograph final | 2023-04-11 |
| 24 alopecia reliefshampoo | unapproved drug other | 2020-08-08 |
| 30 day acne treatment kit | OTC monograph final | 2023-08-23 |
| acne clearning treatment | OTC monograph final | 2013-03-20 |
| acne treatment system | C200263 | 2023-10-27 |
| aewajin hasuoshampoo | unapproved drug other | 2022-01-02 |
| anubismed | OTC monograph final | 2023-09-05 |
| black repair hair boosting tonic | unapproved drug other | 2021-03-28 |
| cantharidin 1% / podophyllum resin 5% / salicylic acid 30% | unapproved drug other | 2019-05-17 |
| cellapy haircell | unapproved drug other | 2020-01-21 |
Show 87 more
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ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AE: Other antifungals for topical use in atc
— D01AE12: Salicylic acid
— D02: Emollients and protectives
— D02A: Emollients and protectives
— D02AF: Salicylic acid emollient and protective preparations
M: Musculo-skeletal system drugs
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AC: Preparations with salicylic acid derivatives, topical for joint and muscle pain
N: Nervous system drugs
— N02: Analgesics
— N02B: Other analgesics and antipyretics in atc
— N02BA: Salicylic acid and derivatives, analgesics and antipyretics
P: Antiparasitic products, insecticides and repellents
— P02: Anthelmintics
— P02D: Anticestodals
— P02DA: Salicylic acid derivative anticestodals
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC08: Salicylic acid
HCPCS
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Clinical
Clinical Trials
3453 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | 31 | 42 | 47 | 26 | 60 | 187 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | 7 | 11 | 11 | 134 | 161 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 16 | 16 | 4 | 95 | 129 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 8 | 11 | 6 | 6 | 92 | 119 |
| Ischemic stroke | D000083242 | — | — | 4 | 10 | 16 | 3 | 80 | 108 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 3 | 3 | 8 | 85 | 98 |
| Macular edema | D008269 | — | — | 11 | 18 | 25 | 13 | 35 | 96 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 9 | 29 | 22 | 5 | 26 | 84 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | 8 | 9 | 8 | 13 | 34 | 67 |
| Dental caries | D003731 | EFO_0003819 | K02 | 1 | 5 | 7 | 6 | 51 | 67 |
Show 117 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Temporomandibular joint disorders | D013705 | — | M26.6 | 4 | 4 | 4 | — | 35 | 43 |
| Amblyopia | D000550 | HP_0000646 | H53.00 | 1 | — | 4 | — | 25 | 30 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 1 | 1 | — | 23 | 24 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 3 | 2 | — | 18 | 22 |
| Percutaneous coronary intervention | D062645 | — | — | — | 1 | 3 | — | 17 | 20 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 6 | 1 | — | 12 | 18 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 1 | 3 | — | 11 | 15 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | 1 | 2 | 3 | — | 10 | 15 |
| Hepatic veno-occlusive disease | D006504 | — | K76.5 | — | 5 | 6 | — | 5 | 15 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | — | 11 | 12 |
Show 85 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diaphragmatic hernias congenital | D065630 | — | Q79.0 | — | 3 | — | — | 16 | 19 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | 2 | — | — | 6 | 9 |
| Dental enamel hypoplasia | D003744 | EFO_1001304 | — | 2 | 2 | — | — | 7 | 9 |
| Postoperative pain | D010149 | — | G89.18 | 1 | 1 | — | — | 6 | 8 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | 5 | 7 |
| Reperfusion injury | D015427 | — | — | 1 | 1 | — | — | 6 | 7 |
| Nervous system diseases | D009422 | — | G00-G99 | — | 1 | — | — | 5 | 6 |
| Stable angina | D060050 | — | I20.89 | — | 1 | — | — | 5 | 6 |
| Basal cell neoplasms | D018295 | — | — | 3 | 3 | — | — | 2 | 6 |
| Sleep bruxism | D020186 | — | G47.63 | 1 | 1 | — | — | 4 | 6 |
Show 109 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | 7 | 8 |
| Blood pressure | D001794 | EFO_0004325 | — | 2 | — | — | — | 5 | 7 |
| Heart arrest | D006323 | EFO_0009492 | I46 | 1 | — | — | — | 6 | 7 |
| Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | 2 | — | — | — | 5 | 7 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 5 | 6 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | — | — | — | 5 | 6 |
| Amyotrophic lateral sclerosis | D000690 | HP_0007354 | G12.21 | 2 | — | — | — | 3 | 5 |
| Endovascular procedures | D057510 | — | — | 1 | — | — | — | 3 | 4 |
| Aortic dissection | D000784 | — | I71.0 | 1 | — | — | — | 3 | 4 |
| Vascular calcification | D061205 | — | — | 1 | — | — | — | 2 | 3 |
Show 45 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malocclusion | D008310 | HP_0000689 | M26.4 | — | — | — | — | 10 | 10 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | — | — | — | 9 | 9 |
| Mandibular fractures | D008337 | — | S02.6 | — | — | — | — | 9 | 9 |
| Bruxism | D002012 | — | F45.8 | — | — | — | — | 8 | 8 |
| Muscle weakness | D018908 | HP_0001324 | — | — | — | — | — | 8 | 8 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 8 | 8 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 7 | 7 |
| Edentulous jaw | D007575 | — | — | — | — | — | — | 7 | 7 |
| Temporomandibular joint dysfunction syndrome | D013706 | — | — | — | — | — | — | 7 | 7 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 7 | 7 |
Show 501 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Salicylic acid |
| INN | — |
| Description | Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. It is obtained from the bark of the white willow and wintergreen leaves. It has a role as an antiinfective agent, an antifungal agent, a keratolytic drug, an EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor, a plant metabolite, an algal metabolite and a plant hormone. It is a conjugate acid of a salicylate. |
| Classification | Small molecule |
| Drug class | anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)c1ccccc1O |
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Salicylic acid
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Salicylic acid
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Safety
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34,512 adverse events reported
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